| COMMISSIONED ARTICLE |
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| Year : 2016 | Volume
: 4
| Issue : 3 | Page : 163-170 |
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High-risk penetrating keratoplasty
Shilpa Ajit Joshi, Madan Deshpande
Department of Cornea and Ocular Surface, PBMA's H V Desai Eye Hospital, Pune, Maharashtra, India
Correspondence Address:
Shilpa Ajit Joshi
Department of Cornea and Ocular Surface, PBMA's H V Desai Eye Hospital, Hadapsar, Pune - 411 060, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2320-3897.190792
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Background: Loss of immune privilege has important connotations for graft survival, often in clinical scenarios where the other eye is irreversibly blind. This article looks at the state of the evidence-based treatment available for high-risk penetrating keratoplasty (P.K.). Materials and Methods: Review of pathophysiological and immunological mechanisms present was done. Conclusion: Pre-, intra-, and post-operative considerations in P.K. in high-risk situation along with the role of immune-suppression are discussed. Success in high-risk keratoplasty depends on an ongoing effort during as well as life-long after P.K. The role of nonimmunological factors such as glaucoma, reactivation of infection, and unstable ocular surface are important determinants in graft failure. |
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