Journal of Clinical Ophthalmology and Research

REVIEW ARTICLE
Year
: 2022  |  Volume : 10  |  Issue : 1  |  Page : 3--8

The oxidative and inflammatory nature of age-related macular degeneration


Rogil Jose de Almeida Torres1, Rogerio Joao de Almeida Torres2, Andrea Luchini3, Ana Lucia Anjos Ferreira1 
1 State University of Botucatu, UNESP, Campina Grande do Sul, Brazil
2 Department of Ophthalmology, Hospital Angelina Caron, Campina Grande do Sul, Brazil
3 Ophthalmologic Center of Curitiba

Correspondence Address:
Rogil Jose de Almeida Torres
Rua Emiliano Perneta, 390, Conjunto 1407 - CEP 80420-080, Curitiba, Parana
Brazil

The understanding of the effects of oxidation and inflammation on age-related macular degeneration (AMD) genesis has been of utmost importance for the advancement of preventive and therapeutical measures adopted in this disease. Several studies have been conducted on lifestyles, dietary antioxidants, expression of antioxidant enzymes, naturally found in the retina, as well as expression of cytokines, enzymes, and growth factors, with an ultimate goal to prevent or mitigate the visual damage induced by AMD. This article details the disruption of redox homeostasis associated with the increase of cells and inflammatory markers, major factors in triggering and/or aggravating the degenerative macular disease. The data sources used in this review study include Cochrane Database of Systematic Reviews, PubMed, MedlinePlus Health Information, and Elsevier Science.


How to cite this article:
de Almeida Torres RJ, de Almeida Torres RJ, Luchini A, Anjos Ferreira AL. The oxidative and inflammatory nature of age-related macular degeneration.J Clin Ophthalmol Res 2022;10:3-8


How to cite this URL:
de Almeida Torres RJ, de Almeida Torres RJ, Luchini A, Anjos Ferreira AL. The oxidative and inflammatory nature of age-related macular degeneration. J Clin Ophthalmol Res [serial online] 2022 [cited 2022 May 16 ];10:3-8
Available from: https://www.jcor.in/article.asp?issn=2320-3897;year=2022;volume=10;issue=1;spage=3;epage=8;aulast=de;type=0